Selank is a nootropic, anxiolytic peptide based drug developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Selank is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It is a synthetic analogue of a human tetrapeptide tuftsin.
Selank is a synthetic analogue of the immunomodulatory peptide tuftsin; as such, it mimics many of its effects. It has been shown to modulate the expression of Interleukin-6 (IL-6) and affect the balance of T helper cell cytokines. It has been shown to influence the concentration of monoamine neurotransmitters and induce metabolism of serotonin. There is evidence that it may also modulate the expression of brain-derived neurotropic factor (BDNF) in rats.
Selank, as well as a related peptide drug, semax, have been found to inhibit enzymes involved in the degradation of enkephalins and other endogenous regulatory peptides, and this action may be involved in their effects.
COA:
Function:improvement of learning and memory processes
increased sensory attention
increased curiosity
increased mental clarity
restoration of balance of serotonergic and noradrenergic brain system activity
anti-anxiety - inhibition of anxiety
antiviral activity with no negative effects
psychostimulant, anti-asthenic - increased mental energy
stabilization of mood and overall feeling of wellbeing
reversal of anhedonia
potential restoration of catecholaminergic system functions after damage due to abuse reference
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