Product Information:
A'icar is a cell permeable activator of AM, a metabolic master regulator that is activated in times of reduced energy availability (high cellular AM:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMK with A'icar mimics exercise and triggers insul-independent glucose uptake by skeletal muscle.
| Name | A'ICAR |
| CAS | 2627-69-2 |
| MF | C9H14N4O5 |
| MW | 258.23 |
| EINECS | 220-097-5 |
| Product Categories | Carbohydrates & Derivatives;Nucleotides;Protein Kinase;Cardiovascular |
| Chemical Properties | white or off-white solid |
| Assay | 99% |
| Usage | A'ICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown . Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective. |
Usage: A'ICAR (AICA-Riboside) strongly inhibits the transcription of PPARα and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that A'ICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that A'ICAR can mimic the activity of insul (sc-211647) by activating AMK (AM-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).
COA:
| Items of analysis | Specification | Results |
| Description | White powder, or Off-White Solid powder | Off-White Powder |
| Identification | H-NMR LCMS | Conform |
| Melting point | 215 - 216 ºC | Complies |
| Loss on drying | ≤0.5 % | 0.18% |
| Heavy metals | ≤10ppm | Conform |
| Total impurities | ≤3.0 % | 0.75% |
| Assay | (HPLC) > 98.0 % | 99.10% |
| Conclusion | Qualified |
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Product Categories : Sarms Liquid
