Temorelin acetate is a synthetic analogue of GRF. Similar to endogenous GRF, it acts by binding and activating GRF receptors in vitro. GRF is a hypothalamic regulatory polypeptide that stimulates the synthesis and release of endogenous growth hormone (GH) by pituitary growth-stimulated Chemicalbook cells. GH exerts pharmacological effects by interacting with specific receptors in target cells including chondrocytes, osteoblasts, cardiomyocytes, hepatocytes and adipocytes.
Timorelin is composed of 44 amino acid sequences of human growth hormone releasing factor (GRF), with 3-hexenyl group attached to its tyrosine N-terminal residue. The molecular formula is C221H366N72O67s.XC2H4O (x≈7), and the relative molecular weight (free base) is 5135.9. Chemicalbook, a novel growth hormone releasing factor, can not only normalize growth hormone secretion in vivo, but also reduce the increased visceral adipose tissue (VAT), improve dyslipidemia and quality of life, and maintain glucose homeostasis in vivo. The drug was approved by the FDA in November 2010 for the treatment of HIV-associated lipodysmorphic syndrome.
COA:
Function:It has antioxidant effecTemorelin is a synthetic analogue of growth hormone releasing factor (GRF). Similar to endogenous GRF, it acts by binding and activating GRF receptors in vitro. GRF is a hypothalamic regulatory polypeptide that stimulates the synthesis and release of endogenous growth hormone (GH) by Chemicalbook somatogonin cells. GH exerts pharmacological effects by interacting with specific receptors in target cells including chondrocytes, osteoblasts, cardiomyocytes, hepatocytes and adipocytes. 
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