Company Details
Shaanxi YXchuang Biotechnology Co., Ltd
Unit Price: | USD 80 - 90 / Box |
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Payment Type: | L/C,T/T,D/P,Paypal |
Incoterm: | FOB,CFR,CIF,EXW,FCA,CPT,CIP |
Model No.: YXchuang - Pnc-27
Brand: YXchuang
Place Of Origin: China
Types Of: Pharmaceutical Intermediates
Specific Optical Rotation (c=0.5,10% HAc: 50.0~-60.0°
Shelf Life: 2 Years
Appearance: Powder, White To Off-White Crystalli
Purity: 99%
Usage: Animal Pharmaceuticals
Grade Standard: Medicine Grade
Product Name: Follistatin 344
Storage: 2-8ºc
Packaging: aluminium foil bag
Productivity: 100000kg
Transportation: Ocean,Land,Air,Express
Place of Origin: china
Supply Ability: 1000000 KG
Certificate: ISO COA
HS Code: YXchuang
Port: Any Port
Payment Type: L/C,T/T,D/P,Paypal
Incoterm: FOB,CFR,CIF,EXW,FCA,CPT,CIP
Product Information
PNC-27 is a membrane-active peptide that binds to the HDM-2 protein expressed in the cancer cell membranes of solid tissue tumor cells and induces transmembrane pore formation in cancer, but not in normal cells, resulting in tumor cell necrosis that is independent of p53 activity in these cells.
PNC-27 is a peptide that contains p53 protein amino acid residues 12-26 of its HDM-2 binding domain attached to a transmembrane-penetrating sequence, also called the membrane residency peptide (MRP). Both PNC-27 and PNC-28 (which has a sequence that is identical to that of PNC-27 but lacks the first six amino acid residues of PNC-27 (i.e., p53 residues 17-26) are lethal to a wide variety of cancer cells with IC50 values ranging from around 75 ug/ml (18.6 uM) to 200 ug/ml (50 uM). On the other hand, neither peptide affects normal or untransformed cells in culture, including human hematopoietic stem cells even at the highest doses (around 500 ug/ml) tested. The latter finding suggests that both peptides would not be toxic to bone marrow function in contrast to the effects of many chemotherapeutic agents.
Sequence: PPLSQETFSDLWKLL
Molecular formula: C84H128N18O24
Molecular weight: 1772.93
Quantity in stock : 10 grams
Purity: >98.0%
Packing : According to clients' requirements
Source : synthetic
Keywords : PNC-27
Product photos:
Functions
About us:
Company Profile
Our company offers variety of products which can meet your multifarious demands.including API Powder、Pharmaceutical Intermediates、Vitamins Powder、Plant Extracts、Food Additive、Peptide Powder and so on We adhere to the management principles of "quality first, customer first and credit-based" since the establishment of the company and always do our best to satisfy potential needs of our customers. Our company is sincerely willing to cooperate with enterprises from all over the world in order to realize a win-win situation since the trend of economic globalization has developed with anirresistible force.
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FAQ:
Q1: Are you a manufacturer?
Answer: Yes
Q2: How to contact with us?
Click the Google "Contact Supplier" And then send us message the product you interest in, you will get reply within 24 hours.
Q3:Which kind of payment terms do you accept?
For small order,you can pay by T/T,Western Union or online ,nomal order by T/T to our company account
Q4:Can you give me a discount price?
Surely,It depend on your qty
Q5:How can i get a sample?
free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.
Q6: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q7:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us,
we will send you free goods for replacement or refund your loss.
Product Categories : API Powder > N Isopropylbenzylamine