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Axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline in the intrinsic axon growth potential , and one of the strategies to stimulate axon growth in injured neurons involves pharmacological manipulation of implicated signaling pathways.here we report phenotypic cell-based screen of chemical libraries and structure-activity-guided optimization that resulted in the identification of compound 7p which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. in an animal model of optic nerve injury, compound 7p was shown to induce growth of gap-43 positive axons, indicating that the in vitro neurite outgrowth activity of compound 7p translates into stimulation of axon regeneration in vivo.further optimization of compound 7p and elucidation of the mechanisms by which it elicits axon regeneration in vivo will provide a rational basis for future efforts to enhance treatment strategies.
| CAS No. | 1890208-58-8 |
| Category | API |
| Quality Standard | EP/USP |
| MSDS | Available |
| COA | Contact with Effy for updated version COA. |
| Sample | Available |
| MOQ | 5g |
| Delivery Date | In 3 days |
| Place Of Origin | China |
| Application | Pharmaceutical raw materials |
| Brand Name | QDXIGEMA |
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Yxchuang today it has been graduallymove from singleness to high-tech mode enterprise, focusing on production,R&D, Sales andOEM. A large-scale enterprise with 55,000 square meter of modernized new factory buildings andoffice buildings, 35,000 square meter standardized clean room, 100,000 grade cleaned room, and2000 square meter high standard laboratory.
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