Angiotensin ⅱ is produced by renin acting on angiotensinogen to produce angiotensin ⅰ, which is then produced by invertase. Angiotensin ii has high biological activity and is the most effective pressurizing substance. The pressurizing effect of angiotensin II is 40 times that of supradenine of norepadrenal gland. It can also stimulate the adrenal gland to secrete adrenaline and aldosterone.Angiotensin ⅱ is produced by renin acting on angiotensinogen to produce angiotensin ⅰ, which is then produced by invertase. Angiotensin ii has high biological activity and is the most effective pressurizing substance. The pressurizing effect of angiotensin II is 40 times that of supradenine of norepadrenal gland. It can also stimulate the adrenal gland to secrete adrenaline and aldosterone.
Function:
1. Angiotensin ⅰ can stimulate the adrenal medulla to secrete adrenaline, but its direct vasoconstriction effect is not obvious;
2, angiotensin II can make the systemic arteriole contraction and increase blood pressure, in addition, can promote the adrenal cortex secretion of aldosterone, aldosterone acts on the renal tubules, sodium, water, potassium discharge, resulting in increased blood volume;
3, through the cell NA-Ca channel, the concentration of Ca ions increases, causing vasoconstriction, thus increasing blood pressure (some drugs for treating hypertension work by antagonizing this effect); The vasoconstriction effect of angiotensin ⅲ was only 1/5 of that of angiotensin ⅱ, but the effect of promoting aldosterone secretion was stronger than that of angiotensin ⅱ.
Under normal circumstances, due to the secretion of renin, blood angiotensin is also less, the regulation of blood pressure has no obvious effect. However, when blood loss occurs, the significant decrease in arterial blood pressure reduces renal blood flow and increases angiotensin production, which plays an important role in preventing excessive blood pressure decline and blood pressure recovery. Renal hypertension may result from decreased renal blood flow and increased angiotensin production in patients with chronic renal vasospasm or stenosis.
APPLICATION:It is used in biochemical and medical research, directly acting on the release of aldosterone in adrenal stimulation, and in medicine for traumatic and post-operative shock and hypotension due to general or lumbar anesthesia.Blood pressure pills. For traumatic or post-operative shock and hypotension due to general or lumbar anesthesia. Adverse reactions and contraindications: sometimes can cause vertigo, headache, occasionally angina pectoris. Too much can cause bradycardia. Hypotension due to excessive blood loss should be replenished. Use with caution if heart function is not complete.
Cause of high angiotensin 2:Angiotensin 2(AngII) is the most important bioactive substance in the renin angiotensin system (RAS). AngII has 40 times the vasoconstriction effect of norepinephrine, and is one of the strongest naturally occurring pressure-boosting substances. Angiotensin II binds to AngII receptors in all tissues. As a system of important effector peptides, mainly through vascular tension Binding of type 1 (AT1) receptor and angiotensin type 2 (AT2) receptor exerts its bioactive effect.AT1 receptor: The receptor that can be blocked by Losartan and DDT is AT1 receptor, which can be divided into two subtypes: AT1A receptor and AT1B receptor [2]. AT1 receptor, especially AT1A, is the most abundant expression in kidney.
related products:HGH, 191AA, growth hormone, etc
Manage products:Steroid, bodybuilding oil, bodybuilding peptide, veterinary medicine, Food Additive, Cosmetic Peptide, API, Plant Extract, puzzle medicine, health care products
Company Profile:
Our company offers variety of products which can meet your multifarious demands.including API Powder、Pharmaceutical Intermediates、Vitamins Powder、Plant Extracts、Food Additive、Peptide Powder and so on We adhere to the management principles of "quality first, customer first and credit-based" since the establishment of the company and always do our best to satisfy potential needs of our customers. Our company is sincerely willing to cooperate with enterprises from all over the world in order to realize a win-win situation since the trend of economic globalization has developed with anirresistible force.
Certification:
Payment Term and Packing Delivery:
FAQ:
Q1: Are you a manufacturer?
Answer: Yes
Q2: How to contact with us?
Click the Google "Contact Supplier" And then send us message the product you interest in, you will get reply within 24 hours.
Q3:Which kind of payment terms do you accept?
For small order,you can pay by T/T,Western Union or online ,nomal order by T/T to our company account
Q4:Can you give me a discount price?
Surely,It depend on your qty
Q5:How can i get a sample?
free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.
Q6: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q7:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us,
we will send you free goods for replacement or refund your loss.
Product Categories : Peptides Products > Peptides Powder
