Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contains the N- and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids has 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-1 binds IGF-IR, IGF-IIR, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF-1 expression is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.
Features and Applications：
Igf-1lr3 is a hormone with a molecular weight of 7.6kd, and its molecular structure is similar to insulin. The main mechanism is to induce intracellular signal transduction by binding to its specific receptor (IGF1R). Igf-1lr3 is one of the most effective activators of Akt signaling pathway. After activating Akt signaling pathway, igf-1lr3 stimulates cell growth and proliferation and inhibits Fine Chemical Book cell apoptosis. Igf-1lr3 adds 13 amino acids to the N-terminal of the complete IGF-1 molecule to form a long-chain IGF-1 with 83 amino acids, and replaces the third amino acid glutamate (E) of IGF-1 molecule with arginine (R), so it is called R3. Compared with unmodified IGF-1, igf-1lr3 has higher stability and biological activity
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