Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle-stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an N-terminal atypical TGF binding domain, three Follistatin domains that contain EGF-like and kazal-like motifs, and a highly acidic C-terminal tail. Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 37.8 kDa protein containing 344 amino acids
COA
| Item | Specifications |
| Product name | |
| Usage | Animal Pharmaceuticals |
| Appearance | White to off-white crystalline powder or lumps |
| Specific Optical Rotation (c=0.5,10% HAc) | 50.0~-60.0° |
| Water Content(Karl Fischer) | ≤5.0% |
| Acetate Content(by HPLC) | ≤15.0% |
| Amino Acid Composition | ±10% of theoretical |
| Purity (by HPLC) | ≥98.0% |
| Single Impurity(by HPLC) | ≤1.0% |
| Peptide Content(by %N) | ≥80% |
| Assay(By Anhydrous, Acetic Acid-free ) | 95.0~105.0% |
| Bacterial Endotoxins | ≤5EU/mg |
| Grade Standard | Medicine Grade |
| COA | Avaliable |
| Storage condition | 2-8ºC |
| Shelf life | 2 years |
Function
In short, follistatin does build muscle but not necessarily in humans.A number of studies support the muscle-building and anti-degenerative effects follistatin in rodents.Unfortunately there is no formal research examining follistatin usage in human subjects but a quick Google search will yield countless amateur follistatin logs on bodbuilding and fitness forums.
When scientists bred a mouse producing no myostatin and extra follistatin it had 117% larger muscle fibers and 73% more total muscle fibers compared to the mice in the control group.This study demonstrates that follistatin positively impacts muscle grow in ways beyond simply suppressing myostatin.Mice with suppressed myostatin had twice the muscle mass but mice with the follistatin transgene and suppressed myostatin had four times as much muscle mass compared to the control group.
Administering FS344 via a small virus (re:Adeno-associated virus/AAV) can increase muscle size and strength in animal species ranging from mice to monkeys with no significant adverse effects on organs, reproductive capabilities, serum estradiol (re:Primary female sex hormone), luteini hormone (L H), and F SH levels.When scientists administered follistatin in mice with spinal muscular atrophy, the mice experienced increased muscle mass, improved motor function, and a 30% longer lifespan compared to mice in the control group.
Not only do increased follistatin levels correlate to increased muscle mass, but a lack of the follistatin protein at birth directly correlates to less muscle mass.Less muscle mass at birth can negatively impact bone, organ, and tissue development as well as normal hormonal function
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