Formation of the vasculature is a complex process, defects in which can lead to embryonic lethality or disease in later life. Understanding mechanisms of vasculogenesis may facilitate the treatment of developmental defects and may be extrapolated to promote wound healing and tissue repair. Thymosin β4 (Tβ4) is an actin monomer binding protein with recognized roles in vascular development, neovascularization and protection against disease.
Vascular network assembly is complex, regulated by multiple signals and cell types; Tβ4 functions in many of the underlying processes, including vasculogenesis, angiogenesis, arteriogenesis, endothelial-mesenchymal transition and extracellular matrix remodeling. Loss of Tβ4 perturbs vessel growth and stability, whereas exogenous application enhances capillary formation and pericyte recruitment, during development and in injury models.
Molecular Formula: C212H350N56O78S
Molecular Weight:4963.4408g/mol
Typical use: Enhancement of immune system responsiveness
Angiogenesis; arteriogenesis; endocardium; endothelial cells;; epicardium; neovascularization; smooth muscle differentiation; thymosin β4; vasculogenesis.
Function:1. 1.Promote endothelial cell migration and angiogenesis
2. Inhibition of apoptosis Tβ4 has a significant protective effect on corneal epithelial cells damaged by exposure to corrosive substances such as benzalchloramine or ethanol. Upregulation of Tβ4 gene is beneficial to enhance the hypoxia resistance of cells.3. Downregulation of key inflammatory molecules Wound healing is a complex biological process that can be divided into three distinct stages: inflammation, cell proliferation, and tissue remodeling. In each stage, the gene expression of related proteins is up-regulated and then down-regulated.4. Stimulating hair follicle development Tβ4 can promote the migration and differentiation of hair follicle stem cells and the reconstruction of extracellular matrix, thereby regulating hair growth.
5. In the treatment of a variety of ocular trauma models, corneal repair thymosin β4 has been shown to promote wound healing after corneal burn and regulate the production of some key cytokines.
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